Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous- violaceous. Tumid lupus erythematosus (TLE), also known as lupus erythematosus tumidus, is a highly photosensitive form of cutaneous lupus erythematosus (cutaneous. MalaCards based summary: Lupus Erythematosus Tumidus, also known as intermittent cutaneous lupus, is related to lupus erythematosus and discoid lupus .

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However, epidermal involvement usually was not found, and smudging of the dermoepidermal junction was only occasionally detected. Indian Dermatology Online Journal.
Create a personal account to register for email alerts with links to free full-text articles. The most affected organ is the skin, which may be involved in isolation or accompanied by systemic manifestations.
Lupus profundus affects subcutaneous tissue. Tumidys access Subscribe now.
Lupus Erythematosus Tumidus: A Unique Disease Entity
LE tumicus classified as autoimmuneas it is associated with pathogenic antibodies directed against components of cell nuclei in various tissues. Treatment consisted of oral prednisone, chloroquine, and topic hydrocortisone lotion. J Am Acad Dermatol. For sex distribution, patients with LET were compared with the control tumidks of patients with other forms of cutaneous LE observed at our department from January 1,through December 31,consisting of 66 male and female patients.
Luus LET is a photosensitive skin disease that is characterized by succulent, edematous, non-scarring plaques. Schmitt, et al, studied the characteristics of 44 patients with CLE, 24 of whom were diagnosed with LET, and found that LET had significantly decreased damage scores and increased mucin deposition, absent interface dermatitis, and tjmidus of hair follicles on histology when compared to other variants of CLE.
Lupus erythematosus tumidus is a separate subtype of cutaneous lupus erythematosus. Lupus tumidus differs in several aspects from the other variants of CCLE, such as the absence of scars when involuted, epidermal atrophy and follicular plugging and adherent hyperkeratotic scaling, all of which are present with discoid lupus. Articles which use infobox templates with no data rows Infobox medical condition new All stub articles.
In all lesions of LET, a distinct subepidermal edema is present, and moderate to copious interstitial mucin deposition is detected with the use of colloidal iron staining. The clinical picture, extreme photosensitivity, histological findings, and effective treatment with antimalarials are so characteristic that LET should be considered as tumdius separate entity and differentiated from other variants of cutaneous LE.
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More than drugs have been associated with the onset of subacute cutaneous LE. Erythematous infiltrated lesion in the thorax with central clearing.
Bull Soc Fr Dermatol Syphiligr. Skin lesions are edematous, urticarialike annular papules and plaques.
Cutaneous lupus erythematosus
Test areas were evaluated until specific lesions appeared for up tumldus 4 weeks after the last irradiation. Register for email alerts with links to free full-text articles Access PDFs of free articles Manage your interests Save searches and receive search alerts. Young women are most often affected, and there is no restriction to race or age. Anais Brasileiros de Dermatologia. Cutaneous manifestations of lupus can be classified into specific subtypes — which include chronic cutaneous lupus erythematosus CCLEsubacute cutaneous lupus erythematosus SCLE and acute cutaneous lupus erythematosus ACLE — and nonspecific skin lesions — such as panniculitis, vasculitis and tumid lesions.
Lupus tumidus is a rare subtype of CCLE, and its diagnosis can be confirmed by the correlation between clinical and histopathological manifestations.

The treatment can also include topical corticosteroids, systemic corticosteroids and high sun protection factor levels 30or higher. Other distinguishing histologic features of the major clinical variants of lupus erythematosus involving the skin are noted in Table 1. Dermatology in General Medicine.
The clinical importance of this edematous, nonscarring, photosensitive type of CCLE as a distinct subset has been neglected in the literature and, since it has not always been considered as a separate entity, we suggest criteria to differentiate LET from PLE, Jessner’s lymphocytic infiltration of the skin, reticular erythematous mucinosis REMpseudolymphoma, SCLE, and other variants of CCLE.
Lupus tumidus was first described by Gougerot and Bournier in By using this site, you agree to the Terms of Use and Privacy Policy. As this disease entity becomes more recognized, there will be an increase growth in incidence and thus a need for larger treatment studies to create an evidence-based algorithmic approach to this unique disease entity, especially in medically complicated cases, such as this young woman.
Mucosal LE presents with plaquesulcers and scaling. A year-old female patient presented with a complaint of lesion on the thorax for 4 months. Direct immunofluorescence examination of biopsy specimens from lesional skin was performed in 5 patients following a standard technique.
Management of skin disease in patients with lupus erythematosus. Histopathology reveals perivascular and periannexal lymphohistiocytic infiltrates in the papillary and reticular dermis and interstitial mucin deposition.
Cutaneous Manifestations of Rheumatic Diseases. National Center for Biotechnology InformationU. Chronic cutaneous lupus erythematosus CCLE has polymorphous presentations that may occasionally mimic other clinical conditions, causing diagnostic difficulties.
Cutaneous lupus erythematosus | DermNet NZ
The diagnosis of lupus tumidus is usually delayed, as it can be confused with other dermatoses due to the absence of systemic manifestations. Privacy Policy Terms of Use. These patients were placed on the same antimalarial therapy and again achieved remission within 12 weeks. InGoerz et al 16 emphasized the extreme photosensitivity as a major characteristic feature of LET and detected a male predominance with the peak of onset from 41 through 50 years of age.
It has been suggested that it is equivalent to Jessner lymphocytic infiltrate of the skin.
Lupus tumidus: a report of two cases
Please review our privacy policy. The primary and the experimentally UV-induced skin lesions demonstrated perivascular and periadnexal superficial and deep lymphocytic infiltration Figure 3.
Features of neonatal cutaneous LE may include:. Histological features of REM show a mild to dense perivascular infiltrate of lymphocytes with abundant mucin deposition in the dermis. llupus
Histologic features of the major clinical variants of lupus erythematosus involving the skin. DermNet NZ does not provide an online consultation service.
Discoid LE is the most common form of chronic cutaneous LE. Because of the rapid and effective improvement of the skin lesions after treatment with antimalarials, systemic corticosteroids or immunosuppressants were temporarily necessary in only 2 patients.
