DOFETILIDE PACKAGE INSERT PDF

Dofetilide (Tikosyn) Considerations for Use*. US/FDA Special Notes. The patient must be registered to receive this drug; the hospital and pharmacy must. Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Tikosyn (Dofetilide). (dofetilide) product monograph and refers you to more detailed information in read the patient package insert and reread it each time therapy is renewed in.

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Post-marketing surveillance has identified very rare cases of ventricular arrhythmias including torsade de pointes TdPusually in patients with severe underlying proarrhythmic conditions.

Mefloquine alone has not been reported to cause QT prolongation.

Severe Because of the potential for TdP, use of sunitinib with dofetilide is contraindicated. Affected cytochrome P isoenzymes: Because of the potential for TdP, use of dofetilide with romidepsin is contraindicated.

Dofetilide – GlobalRPH

Major Coadministration of CYP3A4 inhibitors, such as pxckage, with dofetilide may decrease the metabolism of dofetilide, thereby increasing the potential for QT prolongation. The majority of reports have dofetilie in the setting of mirtazapine overdose or in patients with other risk factors for QT prolongation, including concomitant use of other medications associated with QT prolongation.

Because of the potential for TdP, use of dofetilide with telavancin is contraindicated Telithromycin: Requires a specialized care setting, requires an experienced clinician. Dofetilide is an antiarrhythmic drug with Vaughn Williams Class III cardiac action potential duration prolonging properties. Pakage cardiovascular events including EKG changes i. Alcoholism, cardiac arrhythmias, cardiac disease, coronary artery disease, diabetes mellitus, females, heart failure, hypertension, hypocalcemia, hypokalemia, hypomagnesemia, long QT syndrome, malnutrition, myocardial infarction, QT prolongation, thyroid disease, torsade de pointes.

Because of the potential for QT prolongation or TdP, concurrent use is contraindicated.

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Dofetilide (Tikosyn) | Pharmacy

Severe Coadministration doeftilide dofetilide and azithromycin is contraindicated since there is an increased risk for QT prolongation and torsade de pointes TdP. Gemifloxacin may also prolong the QT interval in some patients. Therefore, dofetilide should only be administered to pregnant women when the benefits to the mother justifies the potential fetal risks.

Halogenated anesthetics can prolong the QT interval. Due to selective and potent blockade of potassium channels, dofetilide prolongs ventricular refractoriness i.

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Concurrent use of verapamil and dofetilide was also associated with a higher occurrence of torsade de pointes in dofetilide clinical trials. Dofetilide terminates induced re-entrant tachyarrhythmias e. Severe Pentamidine has been associated doftilide QT prolongation. Severe Coadministration of ivosidenib with dofetilide is contraindicated due to an increased risk of QT prolongation.

Vemurafenib has paclage associated with QT prolongation. Cases of long QT syndrome and torsade de pointes TdP tachycardia have been described with maprotiline use, but rarely occur when the drug is used alone in normal prescribed doses and in the absence of other known risk factors dofetilied QT prolongation. The likelihood of QTc prolongation may increase with increasing dose of the drug; therefore, the recommended dose should not be exceeded especially in patients with renal or hepatic impairment where the Cmax and AUC are slightly higher.

Moderate Theoretically, bosentan can induce the hepatic metabolism of dofetilide via CYP3A4 isoenzymes. Post-marketing surveillance for ofloxacin has identified very rare cases of torsades de pointes TdP. During clinical trials of dofetilide, potassium concentrations were generally maintained between 3.

QT prolongation and ventricular arrhythmias including fatal TdP have been reported with oxaliplatin use in post-marketing experience. inwert

Grapefruit juice inhibits the cytochrome P 3A4 isozyme in the gut wall. Since bradycardia is a risk factor for development of TdP, the potential occurrence of bradycardia during octreotide administration could theoretically increase the risk of TdP in patients receiving drugs that prolong the QT interval.

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Bepridil has Class I antiarrhythmic properties and is associated with a well-established risk of QT prolongation and TdP.

Osimertinib causes concentration dependent prolongation of the QT interval at docetilide dosing. Additionally, posaconazole has been associated with prolongation of the QT interval as well as rare cases of torsade de pointes; avoid use with other drugs that may prolong the QT interval and are metabolized through CYP3A4, such as inserr.

Severe Because of the potential for torsade de pointes TdPuse of midostaurin with dofetilide is contraindicated. Major Hypokalemia may occur with administration of potassium-depleting drugs such as conivaptan, increasing the potential for dofetilide-induced torsade de pointes. Severe Tacrolimus prolongs the QTc interval. Because of the potential for TdP, use of dofetilide with octreotide is contraindicated. Concurrent use of procainamide should be avoided with other Class III antiarrhythmics amiodarone, ibutilide, sotalol due to the potential for QT prolongation, other side effects, and an increased risk of torsade de pointes.

Because of the potential for TdP, use of dofetilide with nilotinib is contraindicated. According to the manufacturer, it is not known whether dofetilide is excreted into breast milk. Because of the potential for Vofetilide, use of dofetilide with trazodone is contraindicated. There are no quantifiable metabolites circulating in plasma, but five metabolites have been identified in the urine. Severe QT prolongation and ventricular arrhythmias, including torsade de pointes TdP dofetilid death, have been reported with cisapride.

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